This is an impressive uninstaller program that will scan for leftover files after program uninstallations to make sure nothing is left behind. It will also monitor your system for program installs and take note of all changes done to your system, so that it can easily roll them back completely. This happens all the time, in the background, and does not require any user intervention.
But Comodo Programs Manager can do more: it can uninstall both programs and system drivers, and it allows you to redo the uninstall later on (i.e. actually reinstalling the program or driver in case you change your mind and want them back later on). For monitored installations it can actually create installable packages that let you reinstall the application at a later date with all your customized settings.